HPC Jumping Genes and Genomic Dark Matter: New map for human genetics Distribution of putative inter-chromosomal duplications. Chromosomes are shown color-coded in the outermost circle. Inside are lines connecting the origin and the new location (where known) of 58 out of 75 putative inter-chromosomal duplications, colored according to their chromosome of origin. Courtesy of Jan Aerts, Wellcome Trust Sanger InstituteResearchers have created the finest map to date of changes to the structure of human genomes, and a resource for researchers worldwide to look at the role of these changes in human disease. The international team has also identifed 75 ‘jumping genes’ — regions of our genome that can be found in more than one location in some individuals. However, the team cautions that they have not found large numbers of candidates that might alter susceptibility to complex diseases, such as diabetes or heart disease, among the common structural variants. They suggest strategies for finding this ‘dark matter’ of genetic variation.Human genomes differ because of single-letter variations in the genetic code and also because whole segments of the code might be deleted or multiplied in different human genomes. These larger, structural differences are called copy number variants (CNVs). The new research to map and… Read full this story
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